Scientists produce personalised skin cancer vaccine

Two clinical trials for skin cancer have proven that vaccines tailor-made to target a particular patient’s tumours are safe.

The vaccines are detailed in papers published in the Nature journal this July.

Although it does not equate to a cure, the study could combat cancer in humans. They also provide hints about ways to boost the vaccines' power by combining them with treatments that target the immune system, called immunotherapies.

The study took six patients diagnosed with malignant melanoma who had undergone initial treatment.

Naked Scientist Chris Smith explains more.

What they then did was to sequence the DNA of the tumor and then the healthy tissue and compare the two.

Chris Smith, The Naked Scientist

They were looking for were the genetic differences between the tumor and the healthy tissue.

They then used a computer programme to ask of these differences, which ones would be reflected in a difference on the surfaces of cancer cells in terms of the chemical markers they display, and which ones would be most apparent to the immune system.

Chris Smith, The Naked Scientist

Once they got a short list, they made the proteins that those mutated genes would have made in the cancer cells and turned them into a vaccine.

Chris Smith, The Naked Scientist

He says none have had a relapse in two years.

Click on the link below to listen to the full audio....


Recommended

by NEWSROOM AI
Read More
How to get rid of stigma and thrive while living with HIV

How to get rid of stigma and thrive while living with HIV

Eusebius McKaiser chats to brothers Thula and Ntokozo Mkhize on how people can accept and cope with the virus.

10 anger types that escalate to gender-based violence in relationships

10 anger types that escalate to gender-based violence in relationships

Clinical sexologist Dr Eve says words stick and do not heal as fast as wounds.

'Since Ramaphosa became president Motsepe has become bizarre,' says caller

'Since Ramaphosa became president Motsepe has become bizarre,' says caller

Callers react to businessman Patrice Motsepe telling Donald Trump that Africa loves the US president.

Looking at art as one of the languages in which to talk about mental illness

Looking at art as one of the languages in which to talk about mental illness

Eusebius McKaiser and pundits reflect on how people can manage their mental health challenges by creating artworks.

Caller shares horrific story of how his twin babies died at Mamelodi Hospital

Caller shares horrific story of how his twin babies died at Mamelodi Hospital

Mike says immediately after the first baby died, a private undertaker called him offering his services to bury the child.

Parktown Boys' High pupil: The headmaster emphasised we must not speak to anyone

Parktown Boys' High pupil: The headmaster emphasised we must not speak to anyone

A grade 8 learner recalls in graphic detail how he and other boys watched Enoch Mpianzi being swept away by water.

Popular articles
Fitness was a career that chose me - 'Queen Fitnass'

Fitness was a career that chose me - 'Queen Fitnass'

Mapule Ndhlovu opens up about her life journey and how exercise changed not only her body, but her mindset for the better.

[WATCH] Tshwane bystander 'poses' for the camera, has social media laughing

[WATCH] Tshwane bystander 'poses' for the camera, has social media laughing

Khabazela shares tweets and Facebook posts that have gone viral.