Madikizela previously indicated he was considering throwing his hat in the ring for the position.
This is not the first time the provincial DA leader withdraws from the race.
After Mmusi Maimane resigned, he declared his intention to run for interim leader, only to pull out a month later.
He said he decided not to run for the top job because he wants to focus on his role as MEC.
“I said I will consider and then I consulted and applied my mind and came to this decision. But I did consider.”
This article first appeared on EWN : Bonginkosi Madikizela withdraws as contender in DA leadership race